Negative 48 volt

Will the 450m 3ghz run on a -48v power system? Trying to determine if it is isolated or not.

according to the user guide, yes if powered through the CMM5 which supports +/-48vdc on the 56v injector

Yes, this is correct. You can use either + or - 48 VDC. Confirmed in this thread as well:

For the 3 GHz version, direct DC power is required, so this product cannot be powered directly by the CMM5. It has too high a wattage requirement for Power over Ethernet.